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76 Wednesday, July 28, 1999 Reyes Darlina 80 Tuesday, October 19, 1999 Reyes Roberto F. 61 Monday, July 12, 1999 Reynolds Dean 66 Monday, September 27, 1999 Reynolds Leroy Clinton 74 Thursday, October 14, 1999 Reynolds Irma R. 80 Wednesday, May 12, 1999 Richards Ralph Allen 53 Saturday, October 23, 1999 Richards Raymond G. 87 Monday, August 16, 1999 Richins George Arthur Jr.

71 Thursday, July 08, 1999 Richardson Alzine Florence 73 Wednesday, December 08, 1999 Richardson George S. 70 Tuesday, April 27, 1999 Rico Fermin 42 Saturday, June 05, 1999 Rico Carlos Benjamin 45 Thursday, December 31, 1998 Rico Alfonso P. 81 Saturday, August 28, 1999 Rios Soma 34 Monday, August 23, 1999 Rios Julian 46 Sunday, May 23, 1999 Rios Pedro T.

78 Wednesday, October 13, 1999 Ramos Lynn 36 Wednesday, May 05, 1999 Ramos Eduardo 53 Thursday, February 18, 1999 Ramos Rene H.

64 Sunday, April 18, 1999 Ramos Josefa 65 Tuesday, February 23, 1999 Ramos Ramon 67 Thursday, July 22, 1999 Ramos Anita 77 Monday, April 05, 1999 Ramos Carmen G.

Reyes-López, Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona 08193 Bellaterra, Spain, E-mail: Lluis. [email protected]: Allostatic load, Fish, Inflammatory network, Regulatory systems Fish and the other vertebrates subjected to challenges and stressors display a number of responses that involve many physiological compartments and mechanisms.In this review, this role is revisited, in particular focusing in the head kidney, a unique structure with many physiological functions in fish.The repertoire of immune cells and molecules involved in the immune response is shown, paying particular attention to those that present an evolutive and functional difference compared to what is known in mammals.Lesions or parasite occurrence in skin or gills, or local environmental changes in the gut caused by diet composition or pathogens, may also initiate local changes triggering the cytokines- or neural peptides-mediated immune response [1].The physiological effects of waterborne fish diseases remain species-specific, but a common pattern emerges: in fish, the activation of Hypothalamic-Pituitary-Interrenal (HPI) and Brain-Sympathetic-Chromaffin cell (BSC) axis directs the neuroimmunoendocrine crosstalk [2], and the head kidney harbours the cellular scaffold that integrates the stress response.

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