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She starred in and executive produced Drinking Buddies (2013), which co-starred Jake Johnson and Anna Kendrick.She had a supporting role as Jane, a magician's assistant, in The Incredible Burt Wonderstone (2013).She was also in The Death and Life of Bobby Z (2007) and the short-lived NBC drama television series, The Black Donnellys (2007).In September 2007, Wilde joined the cast of the FOX medical-drama television series, House. Remy "Thirteen" Hadley, a secretive and bisexual young internist with Huntington's disease, who was handpicked by House out of a number of applicants to join his medical team.She then worked with American rock band, Red Hot Chili Peppers, directing the music video for their song "Dark Necessities" for their album The Getaway.
Her other paternal ancestors include abolitionist and Anglican minister James Ramsay; politician George Arbuthnot; lawyer, judge, and literary figure Henry Cockburn, Lord Cockburn; Lord Provost of Edinburgh Sir William Arbuthnot; and Sir Thomas Osborne.
Wilde made her directing and writing debut with the film Free Hugs (2011) for Glamour Magazine's short film series, which was screened at various festivals. Remy "Thirteen" Hadley, returned for the series finale of House for two episodes, "Holding On" and "Everybody Dies." She starred alongside Chris Pine in the film People Like Us (2012), Third Person (2012), The Words (2012) and as Liza in Deadfall (2012), a thriller about two siblings who decide to fend for themselves in the wake of a botched casino heist, and their unlikely reunion during another family's Thanksgiving celebration.
She had a supporting role as a blind date in the Spike Jonze drama/romance/sci-fi film Her (2012).
Her first appearance was in the episode, "The Right Stuff." Wilde appeared in the comedy film Year One (2009) as Princess Inanna, alongside Jack Black and Michael Cera.
She starred in Disney's Tron: Legacy (2010) as Quorra, the trusted friend and protector of Kevin Flynn played by Jeff Bridges.